Thursday, June 25, 2015

Tragic destiny

Few people attending the Priestley Medal award presentation in 1941 were surprised when recipient Thomas Midgley Jr. announced that he would demonstrate his key research contributions in experiments and motion pictures instead of deliver a formal acceptance speech. After all, this was a man known as much for his showmanship as for his achievements in chemistry.
Midgley’s career is defined by four major accomplishments. He eliminated the problem of “engine knock” by identifying the gasoline additive tetraethyl lead. He also developed a method to extract large quantities of bromine from seawater when he learned that bromine was needed to prevent tetraethyl lead from corroding engine valves and spark plugs.
In addition, Midgley discovered that dichlorodifluoromethane, also known as Freon, could be used as a nontoxic and nonflammable refrigerant. Finally, his research on natural and synthetic rubber contributed enormously to the scientific literature on these topics.
Before the audience during the 102nd ACS national meeting in 1941 in Atlantic City, N.J., Midgley demonstrated the nontoxic and nonflammable properties of Freon by inhaling the gas and softly exhaling it to extinguish a burning candle. He also demonstrated the antiknock effect of tetraethyl lead in a running engine and did several experiments involving rubber. Since he couldn’t bring the sea into the room, he instead showed a motion picture of bromine being extracted from seawater.
Midgley is considered one of the most creative chemists who ever lived. But he didn’t start out as a chemist. Midgley graduated from Cornell University in 1911 with a degree in mechanical engineering. His first job was as a draftsman and designer for National Cash Register Co. in Dayton, Ohio. A year later, Midgley’s father recruited him to be the first chief engineer, and later superintendent, for Midgley Tire & Rubber Co., a small company the elder Midgley had formed to improve cord tires and tread design.
The company eventually failed, however, and in 1916, Midgley took a job with the newly formed Dayton Engineering Laboratories Co., headed by Charles Kettering. Midgley had learned about Kettering’s research developments while at National Cash Register and became convinced that he also wanted to do research.
Midgley began working with Kettering, and their collaboration proved to be so fruitful that Kettering would later remark that “Midge” was the greatest discovery he had ever made. Midgley affectionately referred to Kettering as “Boss Ket.”
It was Midgley’s love for experimentation that turned him into a chemist. However, his discoveries were not made by accident. Rather, they were guided by his deep familiarity with the periodic table. For example, in searching for an antiknock compound, he knew he was looking for characteristics possessed by elements in a specific region of the periodic table. It then became a process of elimination. He identified the refrigerant dichlorodifluoromethane using a similar approach, but instead of several years, it took him just three days.
Midgley later became vice president of Ethyl Corp., vice president of Kinetic Chemicals, and director of the Ethyl-Dow Chemical Co.
In 1940, Midgley was struck with polio and lost the use of his legs. Despite his disability, he stayed active in the chemistry community, even serving as ACS president in 1944. In his presidential address titled “Accent on Youth,” Midgley pointed out that most great inventions had been made by people between the ages of 25 and 45. He had discovered tetraethyl lead at age 33 and Freon at age 40. He urged older chemists to make room for younger chemists to realize their maximum potential.
Midgley believed that he was no exception. A poet, Midgley concluded his address with the following poem, which seemed to foreshadow his own fate: “When I feel old age approaching, and it isn’t any sport, and my nerves are growing rotten, and my breath is growing short, and my eyes are growing dimmer, and my hair is turning white, and I lack the old ambitions when I wander out at night, though many men my senior may remain when I’m gone, I have no regrets to offer just because I’m passing on, let this epitaph be graven on my tomb in simple style, this one did a lot of living in a mighty little while.”
One month later, on Nov. 2, 1944, Midgley suffocated to death while sleeping, having become entangled in the ropes of a contraption he had invented to help him out of bed. He was only 55.—Linda Wang.

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Understood secret

In AD 383, almost half a century after Constantine the Great, first emperor of the Christian world, was baptized on his death-bed, a twenty-nine-year-old professor of Latin rhetoric whom future centuries would know as Saint Augustine arrived in Rome from one of the empire's outposts in North Africa. He rented a house, set up a school and attracted a number of students who had heard about the qualities of this provincial intellectual, but it wasn't long before it became clear to him that he wasn't going to be able to earn his living as a teacher in the imperial capital. Back home in Carthage his students had been rioting hooligans, but at least they had paid for their lessons; in Rome his pupils listened quietly to his disquisitions on Aristotle and Cicero until it came time to settle the fee, and then transferred en masse to another teacher, leaving Augustine empty-handed So when, a year later, the Prefect of Rome offered him the opportunity of teaching literature and elocution in the city of Milan, and included travelling expenses in the offer, Augustine accepted gratefully.
Perhaps because he was a stranger to the city and wanted intellectual company, or perhaps because his mother had asked him to do so, in Milan Augustine paid a visit to the city's bishop, the celebrated Ambrose, friend and adviser to Augustine's mother, Monica. Ambrose (who, like Augustine, was later to be canonized) was a man in his late forties, strict in his orthodox beliefs and unafraid of even the highest earthly powers; a few years after Augustine's arrival in Milan, Ambrose forced the emperor Theodosius I to show public repentance for ordering a massacre of the rioters who had killed the Roman governor of Salonica. And when the empress Justina requested that the bishop hand over a church in his city so that she could worship according to the rites of Arianism, Ambrose organized a sit-in, occupying the site night and day until she desisted.
According to a fifth-century mosaic, Ambrose was a small, cleverlooking man with big ears and a neat black beard that diminished rather than filled out his angular face. He was an extremely popular speaker; his symbol in later Christian iconography was the beehive, emblematic of eloquence. Augustine, who considered Ambrose fortunate to be held in such high regard by so many people, found himself unable to ask the old man the questions about matters of the faith that were troubling him because, when Ambrose was not eating a frugal meal or entertaining one of his many admirers, he was alone in his cell, reading.
Ambrose was an extraordinary reader. "When he read," said Augustine, "his eyes scanned the page and his heart sought out the meaning, but his voice was silent and his tongue was still. Anyone could approach him freely and guests were not commonly announced, so that often, when we came to visit him, we found him reading like this in silence, for he never read aloud."

Eyes scanning the page, tongue held still: that is exactly how I would describe a reader today, sitting with a book in a cafe across from the Church of St. Ambrose in Milan, reading, perhaps, Saint Augustine's Confessions. Like Ambrose, the reader has become deaf and blind to the world, to the passing crowds, to the chalky flesh-coloured facades of the buildings. Nobody seems to notice a concentrating reader: withdrawn, intent, the reader becomes commonplace.
 To Augustine, however, such reading manners seemed aufficiently strange for him to note them in his Confessions. The implication is that this method of reading, this silent perusing of the page, was in his time something out of the ordinary, and that normal reading was performed out loud. Even though instances of silent reading can be traced to earlier dates, not until the tenth century does this manner of reading become usual in theWest.s

Augustine's description of Ambrose's silent reading (including the remark that he never read aloud) is the first definite instance recorded in Western literature. Earlier examples are far more uncertain. In the fifth century BC, two plays show characters reading on stage: in Euripides' Hippolytus, Theseus reads in silence a letter held by his dead wife; in Aristophanes' The Knights, Demosthenes looks at a writing-tablet sent by an oracle and, without saying out loud what it contains, seems taken aback by what he has read. According to Plutarch, Alexander the Great read a letter from his mother in silence in the fourth century BC, to the bewilderment of his soldiers. Claudius Ptolemy, in the second century AD, remarked in On the Criterion (a book that Augustine may have known) that sometimes people read silently when they are concentrating hard, because voicing the words is a distraction to thought. And Julius Caesar, standing next to his opponent Cato in the Senate in 63 BC, silently read a little billet-doux sent to him by Cato's own sister. Almost four centuries later, Saint Cyril of Jerusalem, in a catechetical lecture probably delivered at Lent of the year 349, entreated the women in church to read, while waiting during the ceremonies, "quietly, however, so that, while their lips speak, no other ears may hear what they say"-a whispered reading, perhaps, in which the lips fluttered with muffled sounds.
 If reading out loud was the norm from the beginnings of the written word, what was it like to read in the great ancient libraries?The Assyrian scholar consulting one of the thirty thousand tablets in the library of King Ashurbanipal in the seventh century BC, the unfurlers of scrolls at the libraries of Alexandria and Pergamum, Augustine himself looking for a certain text in the libraries of Carthage and Rome, must have worked in the midst of a rumbling din. However, even today not all libraries preserve the proverbial silence. In the seventies, in Milan's beautiful Biblioteca Ambrosiana, there was nothing like the stately silence I had noticed in the British Library in London or the Bibliotheque Nationale in Paris. The readers at the Ambrosiana spoke to one another from desk to desk; from time to time someone would call out a question or a name, a heavy tome would slam shut, a cartful of books would rattle by. These days, neither the British Library nor the Bibliotheque Nationale is utterly quiet; the silent reading is punctuated by the clicking and tapping of portable word- processors, as if flocks of woodpeckers lived inside the book-lined halls. Was it different then, in the days of Athens or Pergamum, trying to concentrate with dozens of readers laying out tablets or unfurling scrolls, mumbling away to themselves an infinity of different stories? Perhaps they didn't hear the din; perhaps they didn't know that it was possible to read in any other way. In any case, we have no recorded instances of readers complaining of the noise in Greek or Roman libraries-as Seneca, writing in the first century, complained of having to study in his noisy private lodgings.
Augustine himself, in a key passage of the Confessions, describes a moment in which the two readings-voiced and silent-take place almost simultaneously. Anguished by indecision, angry at his past sins, frightened that at last the time of his reckoning has come, Augustine walks away from his friend Alypius, with whom he has been reading (out loud) in Augustine's summer garden, and flings himself down under a fig-tree to weep. Suddenly, from a nearby house, he hears the voice of a child-boy or girl, he can't say-singing a song whose refrain is tolle, lege, "take up and read". Believing that the voice is speaking to him, Augustine runs back to where Alypius is still sitting and picks up the book he has left unfinished, a volume of Paul's Epistles. Augustine says, "I took hold of it and opened it, and in silence I read the first section on which my eyes fell."The passage he reads in silence is from Romans -an exhortation to "make not provision for the flesh" but to "put ye on [i.e., 'like an armour'] the Lord Jesus Christ". Thunderstruck, he comes to the end of the sentence. The "light of trust" floods his heart and "the darkness of doubt" is dispelled.
Alypius, startled, asks Augustine what has affected him so. Augustine (who, in a gesture so familiar to us across those alien centuries, has marked the place he was reading with a finger and closed the book) shows his friend the text. "I pointed it out to him and he read [aloud, presumably] beyond the passage which I had read. I had no idea what followed, which was this: Him that is weak in the faith receive ye." This admonition, Augustine tells us, is enough to give Alypius the longed-for spiritual strength. There in that garden in Milan, one day in August of the year 386, Augustine and his friend read Paul's Epistles much as we would read the book today: the one silently, for private learning; the other out loud, to share with his companion the revelation of a text. Curiously, while Ambrose's prolonged wordless perusal of a book had seemed to Augustine unexplainable, he did not consider his own silent reading surprising, perhaps because he had merely looked at a few essential words.

Augustine, a professor of rhetoric who was well versed in poetics and the rhythms of prose, a scholar who hated Greek but loved Latin, was in the habit-common to most readers-of reading anything he found written for sheer delight in the sounds.'3 Following the teachings of Aristotle, he knew that letters, "invented so that we might be able to converse even with the absent", were "signs of sounds" and these in turn were "signs of things we think". The written text was a conversation, put on paper so that the absent partner would be able to pronounce the words intended for him. For Augustine the spoken word was an intricate part of the text itself-bearing in mind Martial's warning, uttered three centuries earlier:
The verse is mine; but friend, when you declaim it,
It seems like yours, so grievously you maim it.
 Written words, from the days of the first Sumerian tablets, were meant to be pronounced out loud, since the signs carried implicit, as if it were their soul, a particular sound. The classic phrase scripta manes, verba volat-which has come to mean, in our time, "what is written remains, what is spoken vanishes into air"-used to express the exact opposite; it was coined in praise of the word said out loud, which has wings and can fly, as compared to the silent word on the page, which is motionless, dead. Faced with a written text, the reader had a duty to lend voice to the silent letters, the scripta, and to allow them to become, in the delicate biblical distinction, verba, spoken words-spirit. The primordial languages of the Bible-Aramaic and Hebrew-do not differentiate between the act of reading and the act of speaking; they name both with the same word.
 In sacred texts, where every letter and the number of letters and their order were dictated by the godhead, full comprehension required not only the eyes but also the rest of the body: swaying to the cadence of the sentences and lifting to one's lips the holy words, so that nothing of the divine could be lost in the reading. My grandmother read the Old Testament in this manner, mouthing the words and moving her body back and forth to the rhythm of her prayer. I can see her in her dim apartment in the Barrio del Once, the Jewish neighbourhood of Buenos Aires, intoning the ancient words from her bible, the only book in her house, whose black covers had come to resemble the texture of her own pale skin grown soft with age. Among Muslims too the entire body partakes of the holy reading. In Islam, the question of whether a sacred text is to be heard or read is of essential importance. The ninthcentury scholar Ahmad ibn Muhammad ibn Hanbal phrased it in this manner: since the original Koran-the Mother of the Book, the Word of God as revealed by Allah to Muhammad-is uncreated and eternal, did it become present only in its utterance in prayer, or did it multiply its being on the perused page for the eye to read, copied out in different hands throughout the human ages? We do not know whether he received an answer, because in 833 his question earned him the condemnation of the mihnah, or Islamic inquisition, instituted by the Abassid caliphs. Three centuries later, the legal scholar and theologian Abu Hamid Muhammad al-Ghazali established a series of rules for studying the Koran in which reading and hearing the text read became part of the same holy act. Rule number five established that the reader must follow the text slowly and distinctly in order to reflect on what he was reading. Rule number six was "for weeping.... If you do not weep naturally, then force yourself to weep", since grief should be implicit in the apprehension of the sacred words. Rule number nine demanded that the Koran be read "loud enough for the reader to hear it himself, because reading means distinguishing between sounds", thereby driving away distractions from the outside world.
 The American psychologist Julian Jaynes, in a controversial study on the origin of consciousness, argued that the bicameral mind-in which one of the hemispheres becomes specialized in silent reading- is a late development in humankind's evolution, and that the process by which this function develops is still changing. He suggested that the earliest instances of reading might have been an aural rather than a visual perception. "Reading in the third millennium BC may therefore have been a matter of hearing the cuneiform, that is, hallucinating the speech from looking at its picture-symbols, rather than visual reading of syllables in our sense."
 This "aural hallucination" may have been true also in the days of Augustine, when the words on the page did not just "become" sounds as soon as the eye perceived them; they were sounds. The child who sang the revelatory song in the garden next door to Augustine's, just like Augustine before him, had no doubt learned that ideas, descriptions, true and fabricated stories, anything the mind could process, possessed a physical reality in sounds, and it was only logical that these sounds, represented on the tablet or scroll or manuscript page, be uttered by the tongue when recognized by the eye. Reading was a form of thinking and of speaking. Cicero, offering consolation to the deaf in one of his moral essays, wrote, "If they happen to enjoy recitations, they should first remember that before poems were invented, many wise men lived happily; and second, that much greater pleasure can be had in reading these poems than in hearing them." But this is only a booby-prize tendered by a philosopher who can himself delight in the sound of the written word. For Augustine, as for Cicero, reading was an oral skill: oratory in the case of Cicero, preaching in the case of Augustine.
 Until well into the Middle Ages, writers assumed that their readers would hear rather than simply see the text, much as they themselves spoke their words out loud as they composed them. Since comparatively few people could read, public readings were common, and medieval texts repeatedly call upon the audience to "lend ears" to a tale. It may be that an ancestral echo of those reading practices persists in some of our idioms, as when we say, "I've heard from So-and-so" (meaning "I've received a letter"), or "So-and-so says" (meaning "So-and-so wrote"), or "This text doesn't sound right" (meaning "It isn't well written").
 Because books were mainly read out loud, the letters that composed them did not need to be separated into phonetic unities, but were strung together in continuous sentences. The direction in which the eyes were supposed to follow these reels of letters varied from place to place and from age to age; the way we read a text today in the Western world-from left to right and from top to bottom-is by no means universal. Some scripts were read from right to left (Hebrew and Arabic), others in columns, from top to bottom (Chinese and Japanese); a few were read in pairs of vertical columns (Mayan); some had alternate lines read in opposite directions, back and forth-a method called boustrophedon, "as an ox turns to plough", in ancient Greek.Yet others meandered across the page like a game of Snakes and Ladders, the direction being signalled by lines or dots (Aztec).
 The ancient writing on scrolls-which neither separated words nor made a distinction between lower-case and upper-case letters, nor used punctuation-served the purposes of someone accustomed to reading aloud, someone who would allow the ear to disentangle what to the eye seemed a continuous string of signs. So important was this continuity that the Athenians supposedly raised a statue to a certain Phillatius, who had invented a glue for fastening together leaves of parchment or papyrus. Yet even the continuous scroll, while making the reader's task easier, would not have helped a great deal in disentangling the clusters of sense. Punctuation, traditionally ascribed to Aristophanes of Byzantium (circa 200 BC) and developed by other scholars of the Library of Alexandria, was at best erratic. Augustine, like Cicero before him, would have had to practice a text before reading it out loud, since sight-reading was in his day an unusual skill and often led to errors of interpretation. The fourth- century grammarian Servius criticized his colleague Donat for reading, in Virgil's Aeneid, the words collectam ex llio pubem ("a people gathered from troy") instead of collectam exilio pubem ("a people gathered for exile"). Such mistakes were common when reading a continuous text.
 Paul's Epistles as read by Augustine were not a scroll but a codex, a bound papyrus manuscript in continuous writing, in the new uncial or semi-uncial hand which had appeared in Roman documents in the last years of the third century. The codex was a pagan invention; according to Suetonius, Julius Caesar was the first to fold a roll into pages, for dispatches to his troops. The early Christians adopted the codex because they found it highly practical for carrying around, hidden away in their clothes, texts that were forbidden by the Roman authorities. The pages could be numbered, which allowed the reader easier access to the sections, and separate texts, such as Paul's Epistles, could easily be bound in one convenient package.
 The separation of letters into words and sentences developed very gradually. Most early scripts - Egyptian hieroglyphs, Sumerian cuneiform, Sanskrit-had no use for such divisions. The ancient scribes were so familiar with the conventions of their craft that they apparently needed hardly any visual aids, and the early Christian monks often knew by heart the texts they were transcribing. In order to help those whose reading skills were poor, the monks in the scriptorium made use of a writing method known as per cola et commata, in which the text was divided into lines of sense-a primitive form of punctuation that helped the unsteady reader lower or raise the voice at the end of a block of thought. (This format also helped a scholar seeking a certain passage to find it with greater ease.) It was Saint Jerome who, at the end of the fourth century, having discovered this method in copies of Demosthenes and Cicero, first described it in his introduction to his translation of the Book of Ezekiel, explaining that "what is written per cola et commata conveys more obvious sense to the readers".
 Punctuation remained unreliable, but these early devices no doubt assisted the progress of silent reading. By the end of the sixth century, Saint Isaac of Syria was able to describe the benefits of the method: "I practice silence, that the verses of my readings and prayers should fill me with delight. And when the pleasure of understanding them silences my tongue, then, as in a dream, I enter a state when my senses and thoughts are concentrated. Then, when with prolonging of this silence the turmoil of memories is stilled in my heart, ceaseless waves of joy are sent me by inner thoughts, beyond expectation suddenly arising to delight my heart." And in the mid-seventh century, the theologian Isidore of Seville was aufficiently familiar with silent reading to be able to praise it as a method for "reading without effort, reflecting on that which has been read, rendering their escape from memory less easy". Like Augustine before him, Isidore believed that reading made possible a conversation across time and space, but with one important distinction. "Letters have the power to convey to us silently the sayings of those who are absent," he wrote in his Etymologies. Isidore's letters did not require sounds.
 The avatars of punctuation continued. After the seventh century, a combination of points and dashes indicated a full stop, a raised or high point was equivalent to our comma, and a semicolon was used as we use it today. By the ninth century, silent reading was probably common enough in the scriptorium for scribes to start separating each word from its encroaching neighbours to simplify the perusal of a text -but perhaps also for aesthetic reasons. At about the same time, the Irish scribes, celebrated throughout the Christian world for their skill, began isolating not only parts of speech but also the grammatical constituents within a sentence, and introduced many of the punctuation marks we use today. By the tenth century, to further ease the silent reader's task, the first lines of the principal sections of a text (the books of the Bible, for example) were ordinarily written in red ink, as well as the rubrics (from the Latin for "red"), explanations independent of the text proper. The ancient practice of beginning a new paragraph with a dividing stroke (paragraphos in Greek) or wedge (diple) continued; later the first letter of the new paragraph was written in a slightly larger or upper- case character.

The first regulations requiring scribes to be silent in the monastic scriptoriums date from the ninth century. Until then, they had worked either by dictation or by reading to themselves out loud the text they were copying. Sometimes the author himself or a "publisher" dictated the book. An anonymous scribe, concluding his copying sometime in the eighth century, writes this: "No one can know what efforts are demanded. Three fingers write, two eyes see. One tongue speaks, the entire body labours." One tongue speaks as the copyist works, enunciating the words he is transcribing.
 Once silent reading became the norm in the scriptorium, communication among the scribes was done by signs: if a scribe required a new book to copy, he would pretend to turn over imaginary pages; if he specifically needed a psalter, he'd place his hands on his head in the shape of a crown (in reference to King David); a lectionary was indicated by wiping away imaginary wax from candles; a missal, by the sign of the cross; a pagan work, by scratching his body like a dog.
 Reading out loud with someone else in the room implied shared reading, deliberate or not. Ambrose's reading had been a solitary act. "Perhaps he was afraid," Augustine mused, "that if he read out loud, a difficult passage by the author he was reading would raise a question in the mind of an attentive listener, and he would then have to explain what it meant or even argue about some of the more abstruse points." But with silent reading the reader was at last able to establish an unrestricted relationship with the book and the words. The words no longer needed to occupy the time required to pronounce them. They could exist in interior space, rushing on or barely begun, fully deciphered or only half-said, while the reader's thoughts inspected them at leisure, drawing new notions from them, allowing comparisons from memory or from other books left open for simultaneous perusal. The reader had time to consider and reconsider the precious words whose sounds- he now knew-could echo just as well within as without. And the text itself, protected from outsiders by its covers, became the reader's own possession, the reader's intimate knowledge, whether in the busy scriptorium, the market-place or the home.
 Some dogmatists became wary of the new trend; in their minds, silent reading allowed for day-dreaming, for the danger of accidie- the sin of idleness, "the destruction that wasteth at noonday". But silent reading brought with it another danger the Christian fathers had not foreseen. A book that can be read privately, reflected upon as the eye unravels the sense of the words, is no longer subject to immediate clarification or guidance, condemnation or censorship by a listener. Silent reading allows unwitnessed communication between the book and the reader, and the singular a refreshing of the mind", in Augustine's happy phrase.
 Until silent reading became the norm in the Christian world, heresies had been restricted to individuals or small numbers of dissenting congregations. The early Christians were preoccupied both with condemning the unbelievers (the pagans, the Jews, the Manicheans and, after the seventh century, the Muslims) and with establishing a common dogma. Arguments digressing from orthodox belief were either vehemently rejected or cautiously incorporated by Church authorities, but because these heresies had no large followings, they were treated with considerable leniency. The catalogue of these heretical voices includes several remarkable imaginations: in the second century the Montanists claimed (already) to be returning to the practices and beliefs of the primitive Church, and to have witnessed the second coming of Christ in the form of a woman; in the second half of that century the Monarchianists concluded from the definition of the Trinity that it was God the Father who had suffered on the Cross; the Pelagians, contemporaries of Saint Augustine and Saint Ambrose, rejected the notion of original sin; the Apollinarians declared, in the last years of the fourth century, that the Word, and not a human soul, was united with Christ's flesh in the Incarnation; in the fourth century the Arians objected to the word homoousios (of same substance) to describe the stuff of which the Son was made and (to quote a contemporary jeu de moss) "convulsed the Church by a diphthong"; in the fifth century the Nestorians opposed the ancient Apollinarians and insisted that Christ was also a man; the Eutychians, contemporaries of the Nestorians, denied that Christ had suffered as all humans suffer.
 Even though the Church instituted the death penalty for heresy as early as 382, the first case of burning a heretic at the stake did not occur until 1022, in Orleans. On that occasion the Church condemned a group of canons and lay nobles who, believing that true instruction could only come directly from the light of the Holy Spirit, rejected the Scriptures as "the fabrications which men have written on the skins of animals".4l Such independent readers were obviously dangerous. The interpretation of heresy as a civil offence punishable by death was not given legal basis until 1231, when the emperor Frederick I decreed it as such in the Constitutions of Melfi, but by the twelfth century the Church was already enthusiastically condemning large and aggressive heretical movements that argued not for ascetic withdrawal from the world which the earlier dissenters had proposed) but for a challenge to corrupt authority and the abusive clergy, and for an individual reckoning with the Divinity. The movements spread through tortuous byways, and crystallized in the sixteenth century.
 On October 31, 1517, a monk who, through his private study of the Scriptures, had come to believe that the divine grace of God superseded the merits of acquired faith, nailed to the door of All Saints Church in Wittenberg ninety-five theses against the practice of indulgences -the selling of remission from temporal punishment for condemned sins-and other ecclesiastical abuses. With this act Martin Luther became an outlaw in the eyes of the empire and an apostate in those of the Pope. In 1529 the Holy Roman emperor Charles V rescinded the rights granted to Luther's followers, and fourteen free cities of Germany, together with six Lutheran princes, caused a protest to be read against the imperial decision. "In matters which concern God's honour and salvation and the eternal life of our souls, everyone must stand and give account before God for himself," argued the protesters or, as they were later to be known, Protestants.Ten years earlier, the Roman theologian Silvester Prierias had stated that the book upon which the Church was founded needed to remain a mystery, interpreted only through the authority and power of the pope. The heretics, on the other hand, maintained that people had the right to read the word of God for themselves, without witness or intermediary.
 Centuries later, beyond a sea that for Augustine would have been at the limits of the earth, Ralph Waldo Emerson, who owed his faith to those ancient protesters, took advantage of the art that had so surprised the saint. In church, during the lengthy and often tedious sermons which he attended out of a sense of social responsibility, he silently read Pascal's Pensees. And at night, in his cold room in Concord, "covered with blankets to the chin", he read to himself the Dialogues of Plato. ("He associated Plato," noted a historian, "ever after, with the smell of wool.") Even though he thought there were too many books to be read, and thought readers should share their findings by reporting to one another the gist of their studies, Emerson believed that reading a book was a private and solitary business. "All these books," he wrote, drawing up a list of "sacred" texts that included the Upanishads and the Pensees, "are the majestic expressions of the universal conscience, and are more to our daily purpose than this year's almanac or this day's newspaper. But they are for the closet, and are to be read on the bended knee. Their communications are not to be given or taken with the lips and the end of the tongue, but out of the glow of the cheek, and with the throbbing heart." In silence.

 Observing the reading of Saint Ambrose that afternoon in 384, Augustine could hardly have known what was before him. He thought he was seeing a reader trying to avoid intrusive visitors, sparing his voice for teaching. In fact he was seeing a multitude, a host of silent readers who over the next many centuries would include Luther, would include Calvin, would include Emerson, would include us, reading him today.


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Monday, May 4, 2015

THE BLOOD MYSTERIES


 A group of blood that can cause fatal blood transfusions are proved to be a mystery for 60 years. Now, researchers were able to identify the secret behind blood group known as the "Vel" discovery that could make blood safer for hundreds of thousands of people worldwide.
The mystery began in 1952, when an elderly woman of 66 years in New York, suffering from colon cancer, received a blood transfusion and suffered a sudden reaction, very serious and potentially fatal, in which her body rejected Blood. Doctors who investigated this case refers to the woman, using the name as "patient Vel".
Further research revealed that Ms. Vel has developed a strong immune response to an unknown compound that is found in the blood that had been transfused. However, scientists have not been able to identify this compound, opening the mystery of a new type of blood, "Vel-negative."
"Molecular Basis of Vel-negative blood type remained undiscovered for more than 60 years despite intense efforts worldwide," said Bryan Balliff researcher, biochemist and specialist spectrometry at the University of Vermont.
Most people on Earth are Vel-positive, but after identifying case studies showed that Ms. Vel is not alone. Over 200,000 people in Europe and more than 100,000 people in North America Vel-negative blood type. In Europe, the incidence of this rare type of blood is 1 in 2,500 people, and if these people receive a blood transfusion Vel-positive may suffer from kidney failure and even death.

Each person's red blood cells are coated with molecules that serve as antigens compounds train the immune system to react. It reacts by pumping proteins known as antibodies that attach to antigens and neutralize them. However, normally people do not produce antibodies to their antigens, but only to foreign antigens - such as those obtained from the blood of another person who has a different blood type (and thus antigens that they do not have) .
Most common antigens are those that form the main blood groups: A, B, AB and O. In addition there are many other lesser known blood groups, and Vel, which have the potential to make dangerous transfusions for patients.
Vel-negative blood is one type of blood that can be obtained extremely difficult in many countries. This is partly due to its rarity, but also the fact that there is a systematic method of identifying Vel-negative blood donors. So far, to identify whether a person is Vel Vel-negative or-positive, doctors using antibodies obtained from the few people identified as Vel-negative when their bodies rejected blood transfusion. Many hospitals and blood banks have access to these antibodies, so they have no method to test for Vel.
Now researcher Bryan Baliff alongside Lionel Arnaud, a specialist in molecular biology from the National Blood Transfusion in France have deciphered the mystery of blood type Vel.
"Delivering on our promise to provide healthcare professionals immediate assistance when faced with this rare blood group," commented Baliff.
To identify the missing element in this puzzle, the international team of researchers used antibodies extracted from Vel-negative patients to purify the human erythrocyte membrane protein in Vel. Balliff and colleagues found "guilty", a tiny molecule unnoticed until now they have called SMIM1 (small integral membrane protein 1). Genetic analysis performed on 70 Vel-negative individuals revealed that all patients have missing a gene, the gene that allows cells to produce SMIM1.
Last year, the same researchers have identified two other proteins responsible for rare blood groups, Junior and Langeris. The Vel, the number of blood groups of researchers understood today stands at 33.
"Although there are still some rare blood types that we have not elucidated the molecular Vel-negative blood be certainly the most disturbing mystery," said Arnaud.
Researchers have developed DNA-based tests that allow the identification of patients with Vel-negative. These tests can be easily integrated into existing blood testing procedures, and health professionals can do in less than two hours.
"For those few people with Vel-negative blood who need a blood transfusion, this short period of time could allow life to be saved. Even if you are that rare person Vel-2500 is negative, we know how to quickly find your blood type and how to get your blood that you need, "said Baliff.
Usually people suffer from cancer is only after developing symptoms or after trials and mammograms - signs that are visible only when the cancer has grown and developed so much that it can not be cured. What if a simple blood test could detect early tumor appearance? By sequencing the DNA of the tumor relieves abnormal in a person's blood, scientists are one step closer to a universal blood test to detect cancer. Currently, this technique can detect only advanced cancers, but it seems to be a matter of money: as sequencing costs decrease, say researchers, the test can identify and tumors in infancy.
This effort of researchers is part of a new wave of studies focuses on the cell and DNA released into blood cancers, using these markers to track the growth and spread of tumors and to design treatments. DNA tests seek changes in genes known cancer DNA to distinguish cancerous from normal DNA.
The newest effort in this area was conducted by researchers at Johns Hopkins University. The team consisting of Rebecca Leary, Luis Diaz and Victor Velculescu (professor of oncology and co-director of the Cancer Biology Program at the Johns Hopkins University) wanted to develop a method to identify tumor DNA without knowing the structure genetics. To this end, scientists have started from an interesting observation: regardless of the type of cancer, tumor cells alter the chromosomes (they have extra copies of genes). This suggests that a test can detect chromosomal abnormalities could serve as a general test for cancer identification.
Now, researchers have shown that this idea can be applied. First, they isolated DNA from blood samples provided by 10 patients with advanced colon and breast cancer. Then, using the latest methods of DNA sequencing, researchers have decoded the entire genome of DNA. This showed that all 10 patients suffering from cancer had chromosomal abnormalities, however, when the test was performed on 10 healthy individuals, none present such anomalies.
"This method can have multiple uses," said Velculescu to ScienceNOW. Romanian researcher team wants to use this technique to track a patient's tumor, finding so that it responds to treatment and that grow back after surgical intervention. Also, this test could be used to decide what type of medicine is right for a patient.
Currently, this test is both slow and expensive. Each of the 10 tests conducted in the study cost several thousand dollars and lasted a month. As genome sequencing costs will decrease, "these tests may become extremely cheap," said Velculescu.
"This technique shows great promise, and when sequencing will become accessible, the test could become important in the early detection of cancer," commented Daniel Haber, an expert at the Massachusetts General Hospital specializes in the study of tumor cells.
Another expert, Carlos Caldas from Cancer Research UK Cambridge Research Institute, believes that these tests will start to be used in clinics in 5-10 years.
If the test designed by the team led by Professor Velculescu will prove successful, it could be an important step towards fulfilling forecast Medical Academy President, Professor Irinel Popescu, who announced that Victor Velculescu is one of the two Romanian scholars that are likely to get the Nobel Prize.
Scientists have managed to successfully calculate the rate of aging individuals in birds. Now they hope that this step to help in the development of such a test efficiently in humans.
Test allows us to know the biological age of individuals, predicting accurately their life. The invention works by measuring the length of structures called telomeres, which are known to have the ability to shorten every time cell division occurs. Telomere length provides a more accurate estimation of biological age than chronological age calculation.
As a result of this, some experts thought they could use telomeres estimate how much individuals have to live, assuming that they will die of natural causes.
Such tests have been commonly used on animals, and now scientists have used a small population of songbirds.
In the study, scientists have measured average telomere length in a population of 320 wren on Cousin Island.

"Our results provide the first clear evidence proving the existence of a relationship between each telomere length and mortality for wildlife. I also managed to demonstrate that the rate of telomere shortening may act as an indicator of biological age, "said study author.
The new study showed that telomere length can predict imminent death regardless of age. If birds had telomeres that shorten quickly found that they were to die during the year.
Although telomeres shorten with age, the rate at which this event varies from individual to individual, depending on how the subject experiences the biological stress caused by the changes and effort faced in life.




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WHAT ABOUT SPIDER ?




Scientists have learned that female spider eat their partners after sex

Among spiders, females are more dangerous than males, being famous for having consumed their sexual partners immediately after the act. Until now, however, scientists did not understand why this event occurs. Some biologists suspect that this is because the female is hungry, and the male is a hearty meal at its disposal and can not run. Other biologists consider that male sacrifice their lives for the good of its genes. According to this hypothesis, leaving the eating, the male helps to develop progeny somehow from intercourse.

Dr Peng Yu from Hubei University in China, together with his colleagues decided to find the answer to this question. Research conducted by Chinese researchers published in the journal Behavioral Ecology and Sociobiology science.

Peng's team collected about 400 young wolf-spiders of both sexes, from the nearby plains. Then, the researchers increased spiders separately (to avoid cannibalism) until they reached sexual maturity.

Then, one by one, scientists put a male and every female near waited until there was one of three events: the

male was eaten, coupled with the female and the male was successfully avoided being eaten or the male survived half an hour without eating, but not connected with the female at the time. In some cases, scientists virgin males mated with virgin females in other cases males with female virgins who just germinate. The researchers also mated with female and male virgins who had not been fed for two weeks to test the hypothesis starvation.

Subsequently, the researchers chose 16 females that were mated and then ate sex partners and 10 females mated but have not eaten partners, pursuing their reproductive success. Once submitted cocoon females, the researchers randomly selected 10 cocoons from each group and have them monitored until the chicks have hatched. Later, scientists chose 20 chickens in each group spider to study.

The first observation of the researchers was that, although female wolf spiders eat their males sometimes before intercourse, this happens in 10% of cases, more frequently in females not hungry. The second observation was that when a male is considered to be suitable for mating, it is never eaten during intercourse, even if it may take 90 minutes. Last observation was that in 28% of cases, males were eaten after intercourse. Thus, males who managed to find a sexual partner were consumed more often than those who do not could find one.


The most important discovery of researchers, which explains all others connected with the success of spider offspring. Thus, those born of women who had partners consumed 48% chance of surviving the first month of life. In contrast, those born to women who ate their partners were not only 12% chance of surviving the first 30 days.

Huge difference in the survival rate is high enough, in evolutionary terms, to encourage males to sacrifice, because a male should mate 3 times to get the benefits you get by suicidal act. So why is three times more likely to be used if a male mated with a female unless you did this is probably because he wants to be eaten, for the sake of her progeny.

It is not yet clear what the exact benefits that a male brings her progeny of the female digestive system. It is possible that the spider's body to find essential nutrients that are rare in other foods. Whatever the details, the question biologists is now clear: male spider sacrifice their lives for the sake of their children.





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Wednesday, March 11, 2015

GONUR TEPE

Now more than four millennia, the city-fortress- Gonur - Tepe  and rare housed an advanced civilization that was in the center of a prosperous regions. The fortress lay buried under Kara Kum desert sands in western Turkmenistan.
Gonur-Tepe was discovered by Soviet archaeologists in the last century, and now this mysterious city that once housed thousands of people gradually begin to reveal secrets, archaeologists discovered more artifacts at each excavation.
Huge size of the complex that spans 30 hectares can not be properly appreciated only from the air, where the former buildings of the city seem like a maze in a desert surrounded by large walls.
Located just 50 kilometers from the ancient city of Merv, who worked on the World Heritage List by UNESCO, ruins Gonur-Tepe provides a valuable clue about Archaeological riches of Turkmenistan, one of the most isolated countries in the world.
Around 2000 BC, Gonur-Tepe was the main settlement in the region Margush or Margiana, where there was one of the most sophisticated civilizations of the Bronze Age, but is also very little known.
The archaeological site was covered with sand until the last century when it was discovered by the famous archeologist Viktor Sarianidi. The researcher now has 85 years, but this will not stop the study site in summer.
"I clearly remember the joy I had when I discovered this archaeological treasure. A feeling right under my feet, "he told AFP Russian archaeologist.
Every summer season are performed at Gonur-Tepe excavations, archaeologists make new discoveries confirming the quality and craftsmanship of Bronze Age artisans living in this city which include thousands of people.
City could shape metal craft, knew how to make gold and silver could create objects for religious purposes and could also be carved bone and stone.
"It is amazing to see how advanced these people were techniques. Artisans learned to change the natural shape of the rock at high temperatures and then polished to maintain the new shape, "said archaeologist Nadezhda Dubova.
"This year, Gonur gave us a new surprise, a fantastic mosaic," the expert explained, noting that this object predates the Romans and Greeks period realized mosaics.
Ruins of Gonur-Tepe is the focus of a network of cities and settlements in river delta region in Turkmenistan Morghab flowing from its source in Afghanistan.

Gonur-Tepe is three hours drive from Mary, the most important city of the province, two hours are spent on a bad road which runs along many collective farms abandoned and another hour in a desert land.
Mary, located 380 kilometers from the capital Ashgabat is a typical provincial town, home to 200,000 people and was built mostly in the Soviet style.
30 kilometers of Mary is another glory of the region - the ruins of the great city of Merv, whose importance dates from the Persian Achaemenids era and reached its peak of glory in the twelfth century.
Merv went into terminal decline after being sacked by the Mongols in 1221 after a brutal conquest, led to the deaths of tens of thousands of people. Its ruins are just as abandoned as in Gonur-Tepe.
Most Sultan Sanjar mausoleum treasure is that Merv was led by a city of 200,000 people, and for some time, one of the most populated human settlements in the world.
The mausoleum is covered with a dome with a diameter less than 17 meters. Ruslan Muradov, an architectural historian, says that the mausoleum was revolutionary design.
"Dome design anticipates 300 years Renaissance architect Filippo Brunelleschi great ideas" that project the cathedral dome in Florence, says Muradov.
Unlike the ruins of Gonur-Tepe, Merv was excavated ever since the country where today's Turkmenistan was part of the Russian Empire. Merv included on UNESCO World Heritage List in 1999.
Archaeologists are just beginning to discover the riches of the region Marv, says Viktor Turik, a historian at the Museum of History Marv.
"In the region there are 354 archaeological monuments, and 95% of them have never been studied by experts" said historian.
Turkmenistan remains one of the most isolated countries in the world, but each year the state continues to be visited by few tourists, mostly within specialized tours.
In Marv are only three hotels, President Gurbanguly Berdymukhamedov although recently ordered the construction of a new hotel with 350 beds to encourage tourism.
Authorities have not determined what fate will have extraordinary gold and silver jewelry that archaeologists discovered in this region, but in need of restoration and conservation efforts.
An employee of the authority which manages the national heritage Turkmen say that at one point there were discussions with the Department of Antiquities of the Louvre Museum in Paris, but negotiations failed.

"Many unique discoveries that do not resemble anything ever found in the world, awaiting the moment of glory in museums Turkmen deposits," concluded the employee.



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Wednesday, March 4, 2015

FOREWORD


In today's high-tech society it is important that children develop an interest in science at an early age and see that science is a part of our lives. By becoming comfortable with science at an early age, children can reap many long term benefits. Getting children interested in science does not take a lot of time and effort. Their natural curiosity will ease the way. Making it fun is the key element. The learning process in children happens through play. During play the world is not so threatening. Kids feel safe, secure and capable. They explore on their own. There is an old Chinese saying:

I hear and I forget.
I see and I remember
I do and I understand.
Information and knowledge gained from hands- on activities and self discovery remains in the long term memory.

There is no need for a special place or equipment for teaching science to kids. Most of the materials and  equipment needed can be obtained in home, school, grocery store or local hardware store. Science activity can be carried out with a single kid or group of kids. It can be carried out whenever you want or wherever you want. For example when there is nothing to do and kids are bored. When the weather outside is not friendly. It can be carried out in the kitchen, in the garden, nature hikes, beach trips etc..

Science experiments in our house started in the kitchen. One day when I was baking cookies, my kids were helping. Curious as usual, they started asking questions. “Why do we add sugar?” “Why do we add eggs?” “Why do we have to add baking powder?” At that moment a bulb lighted in my head. We made some cookies without baking powder and compared. This became a hobby. We started experimenting with lot of things, sometimes purely on impulses. But we sure enjoyed that time. Some examples that quickly come to mind are: a) one day when we were folding laundry, some clothes had static. They made small cracking noises and stuck. We had fun learning and experimenting with lot of other things that produce static electricity. b) When we had gone to the beach we started talking about the sea/ocean water being salty and how salt is extracted from the sea water. Kids brought some sea water back home and placed it in sunlight in a shallow tray. In 2-3 days the water evaporated and they collected the salt crystals. The satisfaction in self discovery is incomparable. Without any prompting from me kids also experimented if saltwater freezes faster or tap water.
     

Looking at their interest, pretty soon me and my friend got together and started doing planned experiments with our children in a group setting. Kids enjoyed them and looked forward to the experiment days. Volcanoes and slimes were a lot of fun. When we did an experiment on coloring daisies, (white daisies if placed in colored water, pick up that color. In a few hours their petals start showing the color in the water) it did not end there. Pretty soon more flowers got experimented on and then came the question “Why some flowers pick up colors faster than the others?” One day while we were weeding in the garden we had an amusing finding. There were lots of Lady Bugs on one particular type of weed. That led us to the information on how and why certain bugs favor certain plants or animals. Similarly different kinds of rocks found in the garden piqued kids interest and we ended up doing a project on rocks. 


I was happy to see that I had achieved what I was aiming for: 1) Questioning of observed events leading to finding information. 2) Promotion of independent thinking and reasoning process in the versatile young minds.

This first step “Science is fun” can be followed by the next more exciting step, where kids learn that “Science is also an adventure and challenge.” It often requires some detective work and it requires learning of a methodical step by step approach to solve problems. This approach is called “The scientific method.” The steps in a scientific method can be roughly outlined as follows. 1) If you have to solve a problem start by collecting data. Read books, talk to people, and make observations. 2) Brainstorm- Spend time looking over and understanding the information collected. Have discussions if you are working in a team. 3) Make predictions. 4) Design and carry out experiments. 5) Analyze your results and derive conclusions.

It is a lot more fun to do these activities in a group or as a team. Parents or friends can be very good companions. As kids grow up participation in “science fairs” can also bring a good learning experience. So parents get involved with your kids science activities and share with them the excitement of being a scientist and an explorer. Kids will know that science can be fun. Once they get interested they will keep thinking, investigating and inventing for ever.




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